4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile

Base Information

• Chemical Name: 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile
• CAS No.: 1262328-46-0
• Molecular Formula: C₁₈H₁₁N₃O₆S
• Molecular Weight: 397.368
• Mol file: 1262328-46-0.mol

Synonyms:4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile

Chemical Property of 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile

There total 2 articles about 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

thiazoline-2,4-dione (2295-31-0) + 4-(4-formyl-2-methoxyphenoxy)-3-nitrobenzonitrile (1262328-68-6) → 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile (1262328-46-0)

Guidance literature:

With sodium acetate; In acetonitrile; at 105 ℃;

DOI:10.1021/jm101063h

Reference yield:

4-fluoro-3-nitrobenzonitrile (1009-35-4) + vanillin (121-33-5,8014-42-4) → 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-nitrobenzonitrile (1262328-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 95 °C

2: sodium acetate / acetonitrile / 105 °C

With sodium acetate; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; 2: Knoevenagel condensation;

DOI:10.1021/jm101063h

upstream raw materials:

thiazoline-2,4-dione

4-(4-formyl-2-methoxyphenoxy)-3-nitrobenzonitrile

4-fluoro-3-nitrobenzonitrile

vanillin