methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate

Base Information

• Chemical Name: methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate
• CAS No.: 1449245-06-0
• Molecular Formula: C₂₀H₁₄FN₃O₂
• Molecular Weight: 347.348

Synonyms:methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate

Chemical Property of methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate

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Technology Process of methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate

There total 2 articles about methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3(5)-phenylpyrazol-5(3)-amine (1572-10-7) + methyl 4-(4-fluorophenyl)-2,4-diketobutyrate (39757-34-1) → methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate (1449245-06-0)

Guidance literature:

In ethanol;

DOI:10.1016/j.bmcl.2016.02.072

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate (1449245-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / Inert atmosphere

2: ethanol

With sodium methylate; In ethanol;

DOI:10.1016/j.bmcl.2016.02.072

Reference yield:

methyl 7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate (1449245-06-0) → 2-phenyl-7-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5-carboxylic acid (1017082-08-4)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Reflux;

DOI:10.1016/j.bmcl.2013.03.129

upstream raw materials:

1-(4-fluorophenyl)ethanone

3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine

methyl 4-(4-fluorophenyl)-2,4-diketobutyrate

Downstream raw materials:

N-(6-chlorobenzo[d]thiazol-2-yl)-7-(4-fluorophenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxamide

N-(6-methoxybenzo[d]thiazol-2-yl)-7-(4-methoxyphenyl)-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxamide

N-(6-methoxybenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide

N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

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