N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

Base Information

Chemical Name:N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide
CAS No.:1437792-30-7
Molecular Formula:C₂₉H₂₃N₅O₄S
Molecular Weight:537.599
Hs Code.:

Synonyms:N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

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Chemical Property of N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

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Technology Process of N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

There total 7 articles about N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 29927-08-0
2-amino-5,6-dimethylbenzothiazole

: 1017082-08-4
2-phenyl-7-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5-carboxylic acid

: 1437792-30-7
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 8.16667h;
DOI:10.1016/j.bmcl.2013.03.129

Reference yield:

: 1136-86-3
methyl (3,4,5-trimethoxyphenyl) ketone

: 1437792-30-7
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / tetrahydrofuran / 8 h / 20 °C

2: hydrogenchloride / ethanol / 2 h / Reflux

3: sodium hydroxide / methanol / 2 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8.17 h / 0 - 20 °C

With hydrogenchloride; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.129

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1437792-30-7
N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxy phenyl)pyrazolo [1,5-a]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / tetrahydrofuran / 8 h / 20 °C

2: hydrogenchloride / ethanol / 2 h / Reflux

3: sodium hydroxide / methanol / 2 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8.17 h / 0 - 20 °C

With hydrogenchloride; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.129