1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester
• CAS No.: 1027405-66-8
• Molecular Formula: C₄₆H₅₀N₂O₇
• Molecular Weight: 742.912
• Mol file: 1027405-66-8.mol

Synonyms:1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester

Chemical Property of 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester

There total 6 articles about 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

Boc-Trp-OH (13139-14-5) + 1-((3S,4R)-3-Biphenyl-4-ylmethyl-4-hydroxy-chroman-7-yl)-cyclopentanecarboxylic acid ethyl ester → 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester (1027405-66-8) + 1-{(3R,4S)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester

Guidance literature:

With dmap; diethylcarbamazine; In dichloromethane;

DOI:10.1021/jm00046a001

Reference yield:

4-Phenylbenzaldehyde (3218-36-8) → 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester (1027405-66-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyrrolidine / methanol / Ambient temperature

2: H₂ / 10percent Pd/C / ethyl acetate / 2068.6 Torr

3: 87 percent / Pd(PhCN)2Cl₂, ZnCl₂, P(o-tol)3 / dimethylformamide; 1,2-dimethoxy-ethane / 80 °C

4: NaBH₄ / methanol / Ambient temperature

5: 36 percent / DEC, DMAP / CH₂Cl₂

With pyrrolidine; dmap; sodium tetrahydroborate; bis(benzonitrile)palladium(II) dichloride; diethylcarbamazine; hydrogen; tris-(o-tolyl)phosphine; zinc(II) chloride; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00046a001

Reference yield:

4-oxochroman-7-yl trifluoromethanesulfonate (151884-08-1) → 1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester (1027405-66-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyrrolidine / methanol / Ambient temperature

2: H₂ / 10percent Pd/C / ethyl acetate / 2068.6 Torr

3: 87 percent / Pd(PhCN)2Cl₂, ZnCl₂, P(o-tol)3 / dimethylformamide; 1,2-dimethoxy-ethane / 80 °C

4: NaBH₄ / methanol / Ambient temperature

5: 36 percent / DEC, DMAP / CH₂Cl₂

With pyrrolidine; dmap; sodium tetrahydroborate; bis(benzonitrile)palladium(II) dichloride; diethylcarbamazine; hydrogen; tris-(o-tolyl)phosphine; zinc(II) chloride; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00046a001

upstream raw materials:

Boc-Trp-OH

4-Phenylbenzaldehyde

4-oxochroman-7-yl trifluoromethanesulfonate

Trifluoro-methanesulfonic acid 3-[1-biphenyl-4-yl-meth-(E)-ylidene]-4-oxo-chroman-7-yl ester