(2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester

Base Information

• Chemical Name: (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester
• CAS No.: 137282-18-9
• Molecular Formula: C₂₁H₃₄N₂O₄
• Molecular Weight: 378.512

Synonyms:(2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester

Chemical Property of (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester

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Technology Process of (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester

There total 2 articles about (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-Hydroxy-3-methyl-2-butanone (115-22-0) + L-phenylalanyl-L-leucine methyl ester trifluoroacetate (68835-84-7) → (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester (137282-18-9)

Guidance literature:

With sodium cyanoborohydride; In methanol; Ambient temperature;

DOI:10.1021/jm00083a005

Reference yield: 80.0%

→ Beta-[[2-[[2-[4,5,5-trimethyl-2-oxo-3-oxazolidinyl]-1-oxo-3-phenylpropyl]amino]-4-methyl-1-oxo-pentyl]amino]-alphahydroxycyclohexanebutanoic acid methyl ester (137281-98-2) + (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester (137282-18-9)

Guidance literature:

Reference yield: 79.4%

phosgene (75-44-5) + (2S)-2-<<(2S)-2-<(2-hydroxy-1,2-dimethylpropyl)amino>-3-phenylpropionyl>amino>-4-methylpentanoic acid methyl ester (137282-18-9) → (2S)-4-methyl-2-<<(2S)-3-phenyl-2-(4,5,5-trimethyl-2-oxooxazolidin-3-yl)propionyl>amino>pentanoic acid methyl ester (137282-19-0)

Guidance literature:

With pyridine; In dichloromethane; toluene; at 0 - 10 ℃; for 1h;

DOI:10.1021/jm00083a005

upstream raw materials:

3-Hydroxy-3-methyl-2-butanone

L-phenylalanyl-L-leucine methyl ester trifluoroacetate

Downstream raw materials:

(2S)-4-methyl-2-<<(2S)-3-phenyl-2-(4,5,5-trimethyl-2-oxooxazolidin-3-yl)propionyl>amino>pentanoic acid methyl ester

(2S)-4-methyl-2-<<(2S)-3-phenyl-2-(4,5,5-trimethyl-2-oxooxazolidin-3-yl)propionyl>amino>pentanoic acid

(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-3-phenyl-2-(4,5,5-trimethyl-2-oxooxazolidin-3-yl)propionyl>amino>pentanoyl>amino>butyric acid methyl ester

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