N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

Base Information

Chemical Name:N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide
CAS No.:1354353-83-5
Molecular Formula:C₂₄H₁₈F₂N₄O
Molecular Weight:416.43
Hs Code.:

Synonyms:N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

Suppliers and Price of N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

Chemical Property:

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Technology Process of N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

There total 10 articles about N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 1354353-83-5
N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 3 h / 100 °C

2: hydrogenchloride / water

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1158763-55-3
5-(3-fluorophenyl)picolinic acid

: 1354355-63-7
(2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methanamine

: 1354353-83-5
N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1354353-83-5
N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 3 h / 100 °C

2: hydrogenchloride / water

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; toluene;