2-CHLORO-5-CHLOROMETHYL-3-METHYLPYRIDINE

Base Information

• Chemical Name: 2-CHLORO-5-CHLOROMETHYL-3-METHYLPYRIDINE
• CAS No.: 150807-88-8
• Molecular Formula: C7H7Cl2N
• Molecular Weight: 176.04
• Mol file: 150807-88-8.mol

Synonyms:2-CHLORO-5-CHLOROMETHYL-3-METHYLPYRIDINE

Chemical Property of 2-CHLORO-5-CHLOROMETHYL-3-METHYLPYRIDINE

Chemical Property:

• Melting Point: 59-61 °C
• Boiling Point: 269.4±35.0 °C(Predicted)
• PKA: -0.13±0.10(Predicted)
• PSA: 12.89000
• Density: 1.270±0.06 g/cm3(Predicted)
• LogP: 2.78220

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-(chloromethyl)-3-methylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-CHLOROMETHYL-3-METHYLPYRIDINE

There total 7 articles about 2-CHLORO-5-CHLOROMETHYL-3-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(6-chloro-5-methylpyridin-3-yl)methanol (887707-21-3) → 2-chloro-3-methyl-5-pyridylmethyl chloride (150807-88-8)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.11.026

Reference yield:

2-chloro-2-chloromethyl-4-cyano-4-methylbutyraldehyde (150807-89-9) → 2-chloro-3-methyl-5-pyridylmethyl chloride (150807-88-8)

Guidance literature:

In acetonitrile;

Reference yield:

2-Chloro-5-iodo-3-methylpyridine (59782-89-7) → 2-chloro-3-methyl-5-pyridylmethyl chloride (150807-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / dimethylformamide / 6.5 h / 160 °C

2: diisobutyl aluminum hydride / toluene / 4 h / cooling

3: 89 percent / thionyl chloride / CHCl₃ / 1 h / Heating

With thionyl chloride; diisobutylaluminium hydride; In chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1080/00397910500516134

upstream raw materials:

(6-chloro-5-methylpyridin-3-yl)methanol

2-Chloro-5-iodo-3-methylpyridine

2-chloro-5-cyano-3-methylpyridine

2-chloro-2-chloromethyl-4-cyano-4-methylbutyraldehyde

Downstream raw materials:

N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

(6-chloro-5-methylpyridin-3-yl)methanamine hydrochloride

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY". Page/Page column 84-85. . Retrieved 2012/01/15.
• 2、 Kagabu, Shinzo. "Methyl, trifluoromethyl, and methoxycarbonyl - Introduction to the fifth position on the pyridine ring of chloronicotinyl insecticide imidacloprid". . p. 1235 - 1245. Retrieved 2007/10/03.