6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Base Information

Chemical Name:6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid
CAS No.:1424174-55-9
Molecular Formula:C₂₅H₂₀BCl₂NO₇S
Molecular Weight:560.219
Hs Code.:

Synonyms:6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

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Chemical Property of 6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

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Technology Process of 6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

There total 15 articles about 6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423007-80-0
6-(N-(3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylic acid

: 1424174-55-9
6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Guidance literature:: With hydrogenchloride; sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

: 1423007-77-5
ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

: 1424174-55-9
6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydroxide; methanol / tetrahydrofuran / 5 h / 20 - 60 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride; sodium periodate / water; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; methanol; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1331943-20-4
ethyl 2-(4-chlorophenyl)-5-cyclopropyl-6-nitrobenzofuran-3-carboxylate

: 1424174-55-9
6-{N-[4-borono-3-chlorophenyl]methanesulfonamido}-2-(4-chlorophenyl)-5-cyclopropyl-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / water; ethyl acetate / 8 h / 20 °C / 3000.3 Torr

2.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: sodium hydroxide; methanol / tetrahydrofuran / 5 h / 20 - 60 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

6.1: hydrogenchloride; sodium periodate / water; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; methanol; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; copper diacetate; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;