ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

Base Information

Chemical Name:ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate
CAS No.:1423007-77-5
Molecular Formula:C₂₆H₂₀BrCl₂NO₃
Molecular Weight:545.26
Hs Code.:

Synonyms:ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

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Chemical Property of ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

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Technology Process of ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

There total 11 articles about ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1331943-21-5
ethyl 6-amino-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

: 1217501-28-4
(4-bromo-3-chlorophenyl)boronic acid

: 1423007-77-5
ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; Molecular sieve;

Reference yield:

: 1331943-20-4
ethyl 2-(4-chlorophenyl)-5-cyclopropyl-6-nitrobenzofuran-3-carboxylate

: 1423007-77-5
ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / water; ethyl acetate / 8 h / 20 °C / 3000.3 Torr

2: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; In dichloromethane; water; ethyl acetate;

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1423007-77-5
ethyl 6-((4-bromo-3-chlorophenyl)amino)-2-(4-chlorophenyl)-5-cyclopropylbenzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 3 h / Cooling with ice

1.2: 20 °C

2.1: zinc(II) chloride / ethanol; tert-butyl methyl ether / 2.5 h / 75 - 155 °C / Inert atmosphere

3.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C

4.1: nitric acid / chloroform / 2.5 h / 0 °C / Cooling with ice

5.1: boron trichloride / dichloromethane / 20 h / Cooling with ice; Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C / Cooling with ice; Inert atmosphere

7.1: potassium fluoride; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 20 h / Reflux; Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogenchloride; hydrogen / water; ethyl acetate / 8 h / 20 °C / 3000.3 Torr

9.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

With hydrogenchloride; dmap; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; nitric acid; copper diacetate; boron trichloride; caesium carbonate; triethylamine; sodium bromide; magnesium chloride; zinc(II) chloride; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; tert-butyl methyl ether; chloroform; water; ethyl acetate; toluene; acetonitrile;