^αN-(9-fluorenylmethoxycarbonyl)-^εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine

Base Information

• Chemical Name: ^αN-(9-fluorenylmethoxycarbonyl)-^εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine
• CAS No.: 1037589-70-0
• Molecular Formula: C₄₃H₄₂N₂O₅S
• Molecular Weight: 698.883

Synonyms:^αN-(9-fluorenylmethoxycarbonyl)-^εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine

Chemical Property of ^αN-(9-fluorenylmethoxycarbonyl)-^εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine

Chemical Property:

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Technology Process of ^αN-(9-fluorenylmethoxycarbonyl)-^εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine

There total 5 articles about ^αN-(9-fluorenylmethoxycarbonyl)-^εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NαFmoc-lysine trifluoro acetic acid + 3-(tritylthio) propanoic acid (27144-18-9) → αN-(9-fluorenylmethoxycarbonyl)-εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine (1037589-70-0)

Guidance literature:

3-(tritylthio) propanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 2h;

N_αFmoc-lysine trifluoro acetic acid; With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.333333h;

Reference yield:

3-(tritylthio) propanoic acid (27144-18-9) → αN-(9-fluorenylmethoxycarbonyl)-εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine (1037589-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / ethyl acetate; 1,4-dioxane / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201800793

Reference yield:

3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester (129431-12-5) + Fmoc-Lys-OH (105047-45-8) → αN-(9-fluorenylmethoxycarbonyl)-εN-[3-(triphenylmethylsulfanyl)propionyl]-L-lysine (1037589-70-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2.16667h; pH=8 - 9;

DOI:10.1002/anie.201006867

upstream raw materials:

3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester

Fmoc-Lys-OH

3-(tritylthio) propanoic acid

trityl chloride

Downstream raw materials:

C₉₈H₁₃₅N₁₇O₁₈S

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