6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester

Base Information

• Chemical Name: 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester
• CAS No.: 868754-94-3
• Molecular Formula: C₃₃H₃₅NO₆
• Molecular Weight: 541.644
• Mol file: 868754-94-3.mol

Synonyms:6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester

Chemical Property of 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester

There total 3 articles about 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

t-butyl vinylacetate (14036-55-6) + benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoate (477578-53-3) → 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester (868754-94-3)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 2h; Heating;

DOI:10.1021/ol0520222

Reference yield:

benzyl bromide (100-39-0) → 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester (868754-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / NaHCO₃ / dimethylformamide

2: 73 percent / (PCy₃)Cl₂(C₃H₅N₂Mes₂)Ru=CHPh / CH₂Cl₂ / 2 h / Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol0520222

Reference yield:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid (146549-21-5) → 6-(9H-fluoren-9-ylmethoxycarbonylamino)-hept-3-enedioic acid 7-benzyl ester 1-tert-butyl ester (868754-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / NaHCO₃ / dimethylformamide

2: 73 percent / (PCy₃)Cl₂(C₃H₅N₂Mes₂)Ru=CHPh / CH₂Cl₂ / 2 h / Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol0520222

upstream raw materials:

t-butyl vinylacetate

benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoate

benzyl bromide

2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid