2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide

Base Information

Chemical Name:2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide
CAS No.:1056635-00-7
Molecular Formula:C₂₃H₂₂N₆O₂
Molecular Weight:414.467
Hs Code.:

Synonyms:2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide

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Chemical Property of 2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide

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Technology Process of 2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide

There total 3 articles about 2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1197010-43-7
C₂₀H₂₁N₅O

: 372-09-8
cyanoacetic acid

: 1056635-00-7
2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.ejmech.2020.112148

Reference yield:

: 585-79-5
m-nitrobromobenzene

: 1056635-00-7
2-cyano-N-(3-(((2-(4-morpholinophenylamino)pyrimidin-4-yl)))phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

1.2: 12 h / 100 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 110 °C

3.1: hydrazine hydrate; palladium 10% on activated carbon / ethanol / 2 h / 88 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 16 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; palladium 10% on activated carbon; potassium acetate; N-ethyl-N,N-diisopropylamine; bis(pinacol)diborane; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; isopropyl alcohol;
DOI:10.1016/j.ejmech.2020.112148