(R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Base Information

Chemical Name:(R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide
CAS No.:1600508-20-0
Molecular Formula:C₁₉H₂₅FN₄O₃S
Molecular Weight:408.497
Hs Code.:

Synonyms:(R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

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Chemical Property of (R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

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Technology Process of (R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

There total 6 articles about (R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 694-05-3
1,2,3,6-tetrahydropyridine

: (R)-tert-butyl (5-(5-amino-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate

: 7693-46-1
4-Nitrophenyl chloroformate

: 1600508-20-0
(R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Guidance literature:: With trifluoroacetic acid; In methanol; acetonitrile;

Reference yield:

: 1600511-35-0
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate

: 1600508-20-0
(R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / methanol; dihydrogen peroxide; N,N-dimethyl-formamide; ethyl acetate

2: hydrogenchloride / 1,4-dioxane

3: sodium hydrogencarbonate / 1,4-dioxane

4: sodium azide / water; ethanol

5: water; tetrahydrofuran

6: trifluoroacetic acid / methanol; acetonitrile

With hydrogenchloride; sodium azide; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dihydrogen peroxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: (R)-tert-butyl (2-(5-bromo-2-fluorophenyl)-1-((2-cyanopropan-2-yl)sulfonyl)propan-2-yl)carbamate

: 1600508-20-0
(R)-N-(3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane

2: sodium hydrogencarbonate / 1,4-dioxane

3: sodium azide / water; ethanol

4: water; tetrahydrofuran

5: trifluoroacetic acid / methanol; acetonitrile

With hydrogenchloride; sodium azide; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetonitrile;