3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

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Chemical Name:3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol
CAS No.:1613148-36-9
Molecular Formula:C₃₆H₄₄Cl₂N₄O₈
Molecular Weight:731.673
Hs Code.:

Synonyms:3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

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Chemical Property of 3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

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Technology Process of 3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

There total 11 articles about 3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1613148-10-9
3-bromo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

: 1613148-35-8
N,N-bis(tert-butoxycarbonyl)-3-(1-(2,5-dichlorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

: 1613148-36-9
3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; Inert atmosphere;

Reference yield:

: 54231-35-5
3-fuoro-2-nitropyridine

: 1613148-36-9
3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

1.2: 20 °C

2.1: iron; acetic acid / 1 h / 100 °C

3.1: N-Bromosuccinimide / acetonitrile / 2 h / 0 °C

4.1: triethylamine; dmap / tetrahydrofuran / 75 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 90 °C / Inert atmosphere

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; sodium hydride; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide; acetonitrile; mineral oil;

Reference yield:

: 1184950-48-8
3-bromo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

: 1613148-36-9
3-(6-(bis(tert-butoxycarbonyl)amino)-5-(1-(2,5-dichlorophenyl)ethoxy)pyridin-3-yl)-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-8-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: trifluoroacetic acid / methanol; chloroform / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water;