(E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol

Base Information

• Chemical Name: (E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol
• CAS No.: 236121-34-9
• Molecular Formula: C₁₇H₂₁F₅O₂S
• Molecular Weight: 384.411

Synonyms:(E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol

Chemical Property of (E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol

Chemical Property:

Purity/Quality:

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Technology Process of (E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol

There total 2 articles about (E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

pivalaldehyde (630-19-3) + ((E)-2-Ethoxy-3,3,4,4,4-pentafluoro-but-1-enylsulfanyl)-benzene (236121-25-8) → (E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol (236121-34-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; 1.) -78 deg C;

DOI:10.1021/jo990282p

Reference yield:

phenylthiomethyl triphenylphosphonium chloride (13884-92-9) → (E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol (236121-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: BuLi / tetrahydrofuran / 1.) -38 deg C, 30 min, 2.) room temperature, 3 d

2: 46 percent / BuLi / tetrahydrofuran / 1.) -78 deg C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/jo990282p

Reference yield: 67.0%

(E)-5-Ethoxy-6,6,7,7,7-pentafluoro-2,2-dimethyl-4-phenylsulfanyl-hept-4-en-3-ol (236121-34-9) → (Z)-1,1,1,2,2-Pentafluoro-6,6-dimethyl-4-phenylsulfanyl-hept-4-en-3-one

Guidance literature:

With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; for 0.166667h; Heating;

DOI:10.1021/jo990282p

upstream raw materials:

pivalaldehyde

((E)-2-Ethoxy-3,3,4,4,4-pentafluoro-but-1-enylsulfanyl)-benzene

phenylthiomethyl triphenylphosphonium chloride

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