N⁶-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine

Base Information

• Chemical Name: N⁶-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine
• CAS No.: 137965-06-1
• Molecular Formula: C₆₇H₅₅N₅O₄
• Molecular Weight: 994.205
• Mol file: 137965-06-1.mol

Synonyms:N⁶-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine

Chemical Property of N⁶-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine

There total 4 articles about N⁶-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

bromo-triphenyl-methane (596-43-0) + arabinosyl adenine (5536-17-4) → N6-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine (137965-06-1)

Guidance literature:

With pyridine; at 105 ℃; for 5h;

DOI:10.1248/cpb.56.423

Reference yield:

Acetic acid (2R,3S,4R,5R)-2-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-5-trityloxymethyl-tetrahydro-furan-3-yl ester → N6-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine (137965-06-1)

Guidance literature:

With ammonia; In methanol; for 24h; Yield given;

DOI:10.1021/jo00028a030

Reference yield:

2'-O-Triflyl-3',5'-di-O-trityl-N6-trityladenosine (137965-05-0) → N6-triphenylmethyl-9-(3',5'-bis-O-triphenylmethyl-β-D-arabinofuranosyl)adenine (137965-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hexamethylphosphoric acid triamide / 4 h / Ambient temperature

2: NH₃ / methanol / 24 h

With ammonia; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/jo00028a030

upstream raw materials:

2'-O-Triflyl-3',5'-di-O-trityl-N⁶-trityladenosine

O^3',O^5',N⁶-Tritrityladenosine

bromo-triphenyl-methane

arabinosyl adenine

Downstream raw materials:

9-(3,5-Di-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-N⁶-trityladenine

2'-Deoxy-2'-fluoro-3',5'-di-O-trityl-N⁶-trityladenosine