3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

Base Information

Chemical Name:3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide
CAS No.:1617505-88-0
Molecular Formula:C₂₆H₂₀N₂O₄S₂
Molecular Weight:488.588
Hs Code.:

Synonyms:3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

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Chemical Property of 3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

Chemical Property:

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Technology Process of 3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

There total 4 articles about 3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1617505-82-4
(3-amino-phenyl)(5-(3-ethoxy-phenyl)-thiophen-2-yl)methanone

: 56542-67-7
3-cyanobenzene sulfonyl chloride

: 1617505-88-0
3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

Guidance literature:: With pyridine; Reflux;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 1617505-88-0
3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

4: pyridine / Reflux

With pyridine; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 1: |Friedel-Crafts Acylation / 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074

Reference yield:

: 269745-89-3
(5-bromo-thiophen-2-yl)-(3-nitrophenyl)methanone

: 1617505-88-0
3-cyano-N-(3-(5-(3-ethoxyphenyl)-thiophene-2-yl-carbonyl)phenyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / Inert atmosphere; Reflux

3: pyridine / Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; In methanol; 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.05.074