diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Base Information

Chemical Name:diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate
CAS No.:1026695-75-9
Molecular Formula:C₃₄H₄₄O₅S₂
Molecular Weight:596.852
Hs Code.:

Synonyms:diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

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Technology Process of diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

There total 5 articles about diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 60253-72-7
Trimethyl<(2,4,6-trimethylphenyl)thio>silane

: 208401-64-3
diethyl 2-(3,3-dimethyloxypropyl)-2-(6-oxocyclohex-1-enyl)malonate

: 1026695-75-9
diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1039/b202752f

Reference yield:

: 57346-40-4
diethyl 2-hydroxy-2-(2-oxocyclohexyl)propanedioate

: 1026695-75-9
diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80 percent / TMSOTf / 0.33 h / 0 °C

2.1: 75 percent / Dabco / toluene / 1.5 h / Heating

3.1: NaH / dimethylformamide / 1 h / 0 °C

3.2: 68 percent / Bu₄NI / dimethylformamide / 21 h / 60 °C

4.1: 64 percent / TMSOTf / CH₂Cl₂ / 0.5 h / -78 °C

With 1,4-diaza-bicyclo[2.2.2]octane; trimethylsilyl trifluoromethanesulfonate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b202752f

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1026695-75-9
diethyl 2-[3,3-bis(mesitylsulfanyl)propyl]-2-(6-oxocyclohex-1-enyl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / LDA / tetrahydrofuran / 0.75 h / -78 °C

2.1: 80 percent / TMSOTf / 0.33 h / 0 °C

3.1: 75 percent / Dabco / toluene / 1.5 h / Heating

4.1: NaH / dimethylformamide / 1 h / 0 °C

4.2: 68 percent / Bu₄NI / dimethylformamide / 21 h / 60 °C

5.1: 64 percent / TMSOTf / CH₂Cl₂ / 0.5 h / -78 °C

With 1,4-diaza-bicyclo[2.2.2]octane; trimethylsilyl trifluoromethanesulfonate; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b202752f