4-hydroxy-2-methylbutyric acid ethyl ester

Base Information

• Chemical Name: 4-hydroxy-2-methylbutyric acid ethyl ester
• CAS No.: 80566-57-0
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.186
• Mol file: 80566-57-0.mol

Synonyms:4-hydroxy-2-methylbutyric acid ethyl ester

Chemical Property of 4-hydroxy-2-methylbutyric acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-hydroxy-2-methylbutyric acid ethyl ester

There total 1 articles about 4-hydroxy-2-methylbutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

3-butenyl ethyl carbonate → 4-hydroxy-2-methylbutyric acid ethyl ester (80566-57-0) + 3-methyltetrahydro-2-furanone (1679-47-6)

Guidance literature:

With triisopropoxytitanium(IV) chloride; isopropylmagnesium chloride; In tetrahydrofuran; at -40 ℃;

DOI:10.1021/jo960856f

Reference yield: 100.0%

4-hydroxy-2-methylbutyric acid ethyl ester (80566-57-0) → 3-methyltetrahydro-2-furanone (1679-47-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo960856f

Reference yield: 7.3%

4-hydroxy-2-methylbutyric acid ethyl ester (80566-57-0) → 4-bromo-2-methylbutanoic acid ethyl ester (2213-09-4)

Guidance literature:

With pyridine; N-Bromosuccinimide; triphenylphosphine; In dichloromethane; for 16h;

Downstream raw materials:

3-methyltetrahydro-2-furanone

4-bromo-2-methylbutanoic acid ethyl ester