7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Base Information

Chemical Name:7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene
CAS No.:1180663-50-6
Molecular Formula:C₂₀H₃₁N₃O
Molecular Weight:329.486
Hs Code.:

Synonyms:7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

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Chemical Property of 7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

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Technology Process of 7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

There total 7 articles about 7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1180663-48-2
7-[3-(5-tert-butyl-2-methoxyphenyl)propyl]-1,5,7-triazabicyclo[4.4.0]dec-5-ene

: 1180663-50-6
7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Guidance literature:: 7-[3-(5-tert-butyl-2-methoxyphenyl)propyl]-1,5,7-triazabicyclo[4.4.0]dec-5-ene; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 12.5h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; at 0 ℃;
DOI:10.1021/ja9033999

Reference yield:

: 1180663-44-8
3-(5-tert-butyl-2-methoxyphenyl)acrylic acid

: 1180663-50-6
7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 3800.26 Torr / Autoclave

2.1: lithium aluminium tetrahydride / diethyl ether / 12 h / Inert atmosphere; Reflux

3.1: phosphorus tribromide / toluene / 2 h / Reflux; Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.2: 48 h / 20 °C / Inert atmosphere

5.1: boron tribromide / dichloromethane / 12.5 h / -78 - 20 °C / Inert atmosphere

5.2: 0 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; boron tribromide; phosphorus tribromide; sodium hydride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1021/ja9033999

Reference yield:

: 1180663-45-9
3-(5-tert-butyl-2-methoxyphenyl)propan-1-ol

: 1180663-50-6
7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / toluene / 2 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 12.5 h / -78 - 20 °C / Inert atmosphere

3.2: 0 °C

With boron tribromide; phosphorus tribromide; sodium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja9033999