7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Base Information

Chemical Name:7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene
CAS No.:1180663-52-8
Molecular Formula:C₂₁H₃₁N₃O₂
Molecular Weight:357.496
Hs Code.:

Synonyms:7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

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Chemical Property of 7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

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Technology Process of 7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

There total 8 articles about 7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1180663-50-6
7-[3-(5-tert-butyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

: 1180663-52-8
7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Guidance literature:: With triethylamine; magnesium chloride; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/ja9033999

Reference yield:

: 132098-51-2
2-(3-bromopropyl)-4-tert-butyl-methoxybenzene

: 1180663-52-8
7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 12.5 h / -78 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: triethylamine; magnesium chloride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

With boron tribromide; sodium hydride; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja9033999

Reference yield:

: 1180663-44-8
3-(5-tert-butyl-2-methoxyphenyl)acrylic acid

: 1180663-52-8
7-[3-(5-tert-butyl-3-formyl-2-hydroxyphenyl)propyl]-1,5,7-triazabicyclo[4,4,0]dec-5-ene

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 3800.26 Torr / Autoclave

2.1: lithium aluminium tetrahydride / diethyl ether / 12 h / Inert atmosphere; Reflux

3.1: phosphorus tribromide / toluene / 2 h / Reflux; Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.2: 48 h / 20 °C / Inert atmosphere

5.1: boron tribromide / dichloromethane / 12.5 h / -78 - 20 °C / Inert atmosphere

5.2: 0 °C

6.1: triethylamine; magnesium chloride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; boron tribromide; phosphorus tribromide; sodium hydride; triethylamine; magnesium chloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1021/ja9033999