(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

Base Information

Chemical Name:(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide
CAS No.:1415582-07-8
Molecular Formula:C₃₄H₃₀F₃IN₂O₅S
Molecular Weight:762.588
Hs Code.:

Synonyms:(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

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Chemical Property of (R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

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Technology Process of (R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

There total 16 articles about (R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₂₈F₃IN₂O₄*OS

: 1415582-07-8
(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

Guidance literature:: C₃₅H₂₈F₃IN₂O₄*OS; With potassium trimethylsilonate; In tetrahydrofuran; at 0 - 20 ℃;

With water; sodium hydroxide; In tert-butyl methyl ether;

Reference yield:

: (R)-1-(1-(2,3-bis(benzyloxy)propyl)cyclopropoxy)-4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro[6,7-d]imidazol-2(3H)-one sulfur monoxide

: 1415582-07-8
(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

Guidance literature:: (R)-1-(1-(2,3-bis(benzyloxy)propyl)cyclopropoxy)-4,5-difluoro-3-(2-fluoro-4-iodophenyl)-1H-benzofuro[6,7-d]imidazol-2(3H)-one sulfur monoxide; With potassium trimethylsilonate; In tetrahydrofuran; at 0 - 20 ℃;

With water; sodium hydroxide; In tert-butyl methyl ether;

Reference yield:

: 2367-82-0
1,2,3,5-tetrafluorobenzene

: 1415582-07-8
(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / 2.5 h / 0 - 10 °C / Industry scale

2.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / 20 - 40 °C

3.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 5 °C / Industry scale

3.2: 65 h / 0 - 20 °C / Industry scale

4.1: acetic acid

4.2: 0 - 40 °C

5.1: zinc; ammonium chloride / water; tetrahydrofuran / 2.33 h / 0 - 25 °C

6.1: dichloromethane / 20 - 40 °C

7.1: triethylamine / dmap / dichloromethane

8.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 20 °C

With sulfuric acid; potassium trimethylsilonate; nitric acid; sodium hydride; ammonium chloride; acetic acid; triethylamine; lithium hexamethyldisilazane; zinc; dmap; In tetrahydrofuran; hexane; dichloromethane; water;