(R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Base Information

Chemical Name:(R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
CAS No.:1415582-04-5
Molecular Formula:C₂₀H₁₈F₃IN₂O₅S
Molecular Weight:582.339
Hs Code.:

Synonyms:(R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

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Chemical Property of (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

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Technology Process of (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

There total 21 articles about (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

: 1415582-07-8
(R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide

: 1415582-04-5
(R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Guidance literature:: (R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide; With boron trichloride; In dichloromethane; at -65 - 70 ℃; for 0.5h;

With hydrogenchloride; water; In dichloromethane; at 15 ℃; for 0.25h;

Reference yield:

: 1311401-03-2
1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodo-phenylamino)-benzofuran-7-yl]amide

: 1415582-04-5
(R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

: 1415582-05-6
(S)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Guidance literature:: With Chiralpak AD-H; In methanol; hexane; isopropyl alcohol; at 25 ℃; Purification / work up; Resolution of racemate;

Reference yield:

: 765962-71-8
(2-fluoro-4-iodo-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine

: 1415582-04-5
(R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 5 °C / Industry scale

1.2: 65 h / 0 - 20 °C / Industry scale

2.1: acetic acid

2.2: 0 - 40 °C

3.1: zinc; ammonium chloride / water; tetrahydrofuran / 2.33 h / 0 - 25 °C

4.1: dichloromethane / 20 - 40 °C

5.1: triethylamine / dmap / dichloromethane

6.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 20 °C

7.1: boron trichloride / dichloromethane / 0.5 h / -65 - 70 °C

7.2: 0.25 h / 15 °C

With potassium trimethylsilonate; boron trichloride; sodium hydride; ammonium chloride; acetic acid; triethylamine; zinc; dmap; In tetrahydrofuran; dichloromethane; water;