2-(Trifluoromethyl)-1-iodo-4-nitrobenzene

Base Information

• Chemical Name: 2-(Trifluoromethyl)-1-iodo-4-nitrobenzene
• CAS No.: 400-75-9
• Molecular Formula: C7H3 F3 I N O2
• Molecular Weight: 317.006
• Hs Code.: 2904909090
• Mol file: 400-75-9.mol

Synonyms:Toluene, a,a,a-trifluoro-2-iodo-5-nitro- (8CI); 3-(Trifluoromethyl)-4-iodonitrobenzene;4-Iodo-3-trifluoromethylnitrobenzene

Chemical Property of 2-(Trifluoromethyl)-1-iodo-4-nitrobenzene

Chemical Property:

• Melting Point: 82 °C
• Boiling Point: 273.9±40.0 °C(Predicted)
• PSA: 45.82000
• Density: 2.020±0.06 g/cm3(Predicted)
• LogP: 3.74140

Purity/Quality:

98%min ^*data from raw suppliers

1-Iodo-4-nitro-2-(trifluoromethyl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Trifluoromethyl)-1-iodo-4-nitrobenzene

There total 3 articles about 2-(Trifluoromethyl)-1-iodo-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-nitro-2-trifluoromethyl-aniline (121-01-7) → 1-iodo-4-nitro-2-(trifluoromethyl)benzene (400-75-9)

Guidance literature:

With sodium iodide; sodium nitrite; In sulfuric acid; water;

Reference yield:

N-(4-nitro-2-(trifluoromethyl)phenyl)acetamide (395-68-6) → 1-iodo-4-nitro-2-(trifluoromethyl)benzene (400-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic NaOH

2: acetic acid; sulfuric acid; aqueous sodium nitrite solution; aqueous potassium iodide solution

With sodium hydroxide; sulfuric acid; acetic acid; potassium iodide; sodium nitrite;

DOI:10.1039/jr9510003459

Reference yield:

N-[2-(trifluoromethyl)phenyl]acetamide (344-62-7) → 1-iodo-4-nitro-2-(trifluoromethyl)benzene (400-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄; HNO₃

2: aq.-ethanolic NaOH

3: acetic acid; sulfuric acid; aqueous sodium nitrite solution; aqueous potassium iodide solution

With sodium hydroxide; sulfuric acid; nitric acid; acetic acid; potassium iodide; sodium nitrite;

DOI:10.1039/jr9510003459

upstream raw materials:

4-nitro-2-trifluoromethyl-aniline

N-[2-(trifluoromethyl)phenyl]acetamide

N-(4-nitro-2-(trifluoromethyl)phenyl)acetamide

Downstream raw materials:

2-iodo-5-nitro-benzoic acid

3-(trifluoromethyl)-4-iodobenzenamine

4-nitro-1-(oct-1-ynyl)-2-(trifluoromethyl)benzene

C₃₂H₄₃F₃N₂O₅

Refernces

• 1、 -. "Isoquinoline derivatives with angiogenesis inhibiting activity". . . Retrieved 2008/06/13.