C₂₆H₂₅FO₅S

Base Information

• Chemical Name: C₂₆H₂₅FO₅S
• CAS No.: 1373555-12-4
• Molecular Formula: C₂₆H₂₅FO₅S
• Molecular Weight: 468.546
• Mol file: 1373555-12-4.mol

Synonyms:C₂₆H₂₅FO₅S

Chemical Property of C₂₆H₂₅FO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₅FO₅S

There total 1 articles about C₂₆H₂₅FO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone (1103738-19-7) + (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) (898566-17-1) → C26H25FO5S (1373555-12-4)

Guidance literature:

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene); With isopropylmagnesium chloride; lithium chloride; In tetrahydrofuran; for 1h; Cooling with ice;

((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone; In tetrahydrofuran; for 1h;

Reference yield:

C26H25FO5S (1373555-12-4) → C26H27FO5S

Guidance literature:

C₂₆H₂₅FO₅S; With cerium(III) chloride heptahydrate; In methanol; at 20 ℃; for 0.333333h;

With sodium tetrahydroborate; In methanol; at -78 ℃; for 1h;

With methanol; water;

Reference yield:

C26H25FO5S (1373555-12-4) → C30H31FO9S2 (1373555-86-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: cerium(III) chloride heptahydrate / methanol / 0.33 h / 20 °C

1.2: 1 h / -78 °C

2.1: acetic acid / water / 15 h / 100 °C

2.2: 2 h / 20 °C / Cooling with ice

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C / Cooling with ice

4.1: thiourea / acetonitrile / 1 h / Reflux

5.1: triethylamine / 1 h / 20 °C

6.1: urea hydrogen peroxide adduct / acetonitrile; methanol / 20 °C

With cerium(III) chloride heptahydrate; hydrogen bromide; urea hydrogen peroxide adduct; acetic acid; triethylamine; thiourea; In methanol; water; acetonitrile;

upstream raw materials:

((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholin-4-yl)methanone

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

Downstream raw materials:

(2S,3R,4R,5S,6R)-2-[3-((5-(4-fluorophenyl)thienyl)-2-methylene)-4-chloro-phenyl]-6-methylsulfonyltetrahydropyran-3,4,5-triol

C₃₀H₃₁FO₇S₂

(2S,3R,4R,5S,6R)-2-[3-((5-(4-fluorophenyl)thienyl)-2-methylene)-4-methylphenyl]-6-methylthiotetrahydropyran-3,4,5-triol

C₃₀H₃₁FO₉S₂