2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

Base Information

• Chemical Name: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
• CAS No.: 898566-17-1
• Molecular Formula: C18H14FIS
• Molecular Weight: 408.278
• Hs Code.: 2934999090
• Mol file: 898566-17-1.mol

Synonyms:2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene;2-(5-iodo-2-methylbenzyl)-5-(4-fluoro-phenyl)thiophene;THI045;

Chemical Property of 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

Chemical Property:

• Vapor Pressure: 0-0Pa at 20-25℃
• Melting Point: 109-110 °C
• Refractive Index: 1.643
• Boiling Point: 450.2 °C at 760 mmHg
• Flash Point: 226.1 °C
• PSA: 28.24000
• Density: 1.533 g/cm³
• LogP: 6.05800
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Sparingly), Methanol (Slightly)

Purity/Quality:

99%min ^*data from raw suppliers

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene is an antidiabetic agent and a Canagliflozin (C175190) intermediate. Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and a candidate for the treatment of type 2 diabetes and obesity.

Technology Process of 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene

There total 11 articles about 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanone → (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) (898566-17-1)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; acetonitrile; at 0 - 35 ℃;

Reference yield: 80.0%

2-(4-fluorophenyl)thiophene (58861-48-6) + 5-iodo-2-methylbenzoyl?chloride (108440-70-6) → (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) (898566-17-1)

Guidance literature:

With aluminum (III) chloride; Solvent; Temperature;

Reference yield: 68.4%

[5-(4-fluorophenyl)thiophen-2-yl](5-iodo-2-methylphenyl)methanol → (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) (898566-17-1)

Guidance literature:

With sodium tetrahydroborate; titanium tetrachloride; In 1,2-dimethoxyethane; dichloromethane; at 50 ℃; for 3h;

upstream raw materials:

3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide

2-(4-fluorophenyl)thiophene

5-iodo-2-methylbenzoyl?chloride

ortho-methylbenzoic acid

Downstream raw materials:

1-[1-hydroxy-2,3,4,6-tetra-O-(trimethylsilyl)-β-D-glucopyranosyl]-4-methyl-3-[[5-(4-fluorophenyl)-2-thienyl]methyl]benzene

canagliflozin

(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)

C₂₆H₂₅FO₅S