4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

Base Information

Chemical Name:4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide
CAS No.:1360604-78-9
Molecular Formula:C₁₆H₁₅N₃O₃S
Molecular Weight:329.379
Hs Code.:

Synonyms:4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

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Chemical Property of 4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

Chemical Property:

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Technology Process of 4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

There total 5 articles about 4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360605-13-5
4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

: 1360604-78-9
4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

Guidance literature:: With hydroxylamine; sodium hydroxide; In water; dimethyl sulfoxide; at 65 ℃;

Reference yield:

: 24647-83-4
methyl 4,5-dibromothiophene-3-carboxylate

: 1360604-78-9
4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 2.67 h / -78 - 20 °C

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 60 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

5: hydroxylamine hydrochloride; pyridine / ethanol / 0.17 h / 110 °C / Microwave irradiation; Inert atmosphere

6: acetic anhydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 150 °C / Microwave irradiation

7: sodium hydroxide; hydroxylamine / water; dimethyl sulfoxide / 65 °C

With pyridine; tetrapropylammonium perruthennate; hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 61200-56-4
4,5-dibromothiophene-3-carbaldehyde

: 1360604-78-9
4-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-5-(4-hydroxyphenyl)thiophene-3-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

3: hydroxylamine hydrochloride; pyridine / ethanol / 0.17 h / 110 °C / Microwave irradiation; Inert atmosphere

4: acetic anhydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 150 °C / Microwave irradiation

5: sodium hydroxide; hydroxylamine / water; dimethyl sulfoxide / 65 °C

With pyridine; hydroxylamine hydrochloride; hydroxylamine; acetic anhydride; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; toluene;