4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

Base Information

Chemical Name:4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile
CAS No.:1360605-13-5
Molecular Formula:C₁₆H₁₂N₂O₂S
Molecular Weight:296.349
Hs Code.:

Synonyms:4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

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Chemical Property of 4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

Chemical Property:

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Technology Process of 4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

There total 5 articles about 4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360604-77-8
4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbaldehyde oxime

: 1360605-13-5
4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

Guidance literature:: With acetic anhydride; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 24647-83-4
methyl 4,5-dibromothiophene-3-carboxylate

: 1360605-13-5
4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 2.67 h / -78 - 20 °C

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 60 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

5: hydroxylamine hydrochloride; pyridine / ethanol / 0.17 h / 110 °C / Microwave irradiation; Inert atmosphere

6: acetic anhydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 150 °C / Microwave irradiation

With pyridine; tetrapropylammonium perruthennate; hydroxylamine hydrochloride; acetic anhydride; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;

Reference yield:

: 61200-56-4
4,5-dibromothiophene-3-carbaldehyde

: 1360605-13-5
4-(3,5-dimethylisoxazol-4-yl)-5-(4-hydroxyphenyl)thiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

3: hydroxylamine hydrochloride; pyridine / ethanol / 0.17 h / 110 °C / Microwave irradiation; Inert atmosphere

4: acetic anhydride / 1-methyl-pyrrolidin-2-one / 0.25 h / 150 °C / Microwave irradiation

With pyridine; hydroxylamine hydrochloride; acetic anhydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; water; toluene;