1-bromo-4-fluoro-2-(2-iodophenoxy)benzene

Base Information

• Chemical Name: 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene
• CAS No.: 1325219-90-6
• Molecular Formula: C₁₂H₇BrFIO
• Molecular Weight: 392.994
• Mol file: 1325219-90-6.mol

Synonyms:1-bromo-4-fluoro-2-(2-iodophenoxy)benzene

Chemical Property of 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene

There total 4 articles about 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H9BrFNO (1325219-89-3) → 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene (1325219-90-6)

Guidance literature:

With toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In water; acetonitrile; at 5 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201003559

Reference yield:

1-bromo-4-fluoro-2-(2-nitrophenoxy)benzene (1325219-88-2) → 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene (1325219-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; acetic acid; zinc / ethyl acetate / 0 °C / Inert atmosphere

2: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 5 - 20 °C / Inert atmosphere

With hydrogenchloride; toluene-4-sulfonic acid; acetic acid; potassium iodide; zinc; sodium nitrite; In water; ethyl acetate; acetonitrile;

DOI:10.1002/chem.201003559

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 1-bromo-4-fluoro-2-(2-iodophenoxy)benzene (1325219-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 22 h / 95 °C / Inert atmosphere

2: hydrogenchloride; acetic acid; zinc / ethyl acetate / 0 °C / Inert atmosphere

3: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water; acetonitrile / 5 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; potassium iodide; zinc; sodium nitrite; In water; dimethyl sulfoxide; ethyl acetate; acetonitrile;

DOI:10.1002/chem.201003559

upstream raw materials:

1-bromo-4-fluoro-2-(2-nitrophenoxy)benzene

C₁₂H₉BrFNO

ortho-nitrofluorobenzene

2-bromo-5-fluorophenol

Downstream raw materials:

((2-(2-bromo-5-fluorophenoxy)phenyl)ethynyl)trimethylsilane