(2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate

Base Information

• Chemical Name: (2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate
• CAS No.: 136824-13-0
• Molecular Formula: C₂₂H₂₈O₂Si
• Molecular Weight: 352.549
• Mol file: 136824-13-0.mol

Synonyms:(2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate

Chemical Property of (2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate

There total 1 articles about (2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + (E)-(3R)-Methyl 3-(dimethylphenylsilyl)hex-4-enoate (136174-52-2) → (2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate (136824-13-0) + (E)-(2S,3S)-2-Benzyl-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester (136824-14-1)

Guidance literature:

With n-butyllithium; diisopropylamine; multistep reaction; diastereoselectivity; other (E)-crotylsilane, other electrophiles;

DOI:10.1021/jo00026a030

Reference yield: 72.0%

(2R,3S)-(E)-Methyl 2-benzyl-3-(dimethylphenylsilyl)hex-4-enoate (136824-13-0) → (S)-2-((R)-3-Methyl-4,5-dihydro-isoxazol-5-yl)-3-phenyl-propionic acid methyl ester

Guidance literature:

With nitrosonium tetrafluoroborate; In dichloromethane; for 5h; from -80 deg C to RT;

upstream raw materials:

benzyl bromide

(E)-(3R)-Methyl 3-(dimethylphenylsilyl)hex-4-enoate