R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt

Base Information

• Chemical Name: R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt
• CAS No.: 1385049-51-3
• Molecular Formula: C₉H₁₃N*C₉H₁₇NO₃
• Molecular Weight: 322.448
• Mol file: 1385049-51-3.mol

Synonyms:R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt

Chemical Property of R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt

There total 6 articles about R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(±)?3?(carbamoylmethyl)?5?methylhexanoic acid (181289-15-6) + 1-phenylpropylamine (2941-20-0) → R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt (1385049-51-3)

Guidance literature:

In ethanol; chloroform; at 60 - 63 ℃; for 0.75h;

Reference yield:

5-methyl-3-carboxymethylhexanoic acid (75143-89-4) → R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt (1385049-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetyl chloride / 3.08 h / 20 - 55 °C / Inert atmosphere

2.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C

2.2: pH 2

3.1: chloroform; ethanol / 0.75 h / 60 - 63 °C

With ammonia; acetyl chloride; In ethanol; tert-butyl methyl ether; chloroform; water;

Reference yield:

3-isobutylglutaric anhydride (185815-59-2) → R-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid 1-phenylpropylamine salt (1385049-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 °C

1.2: pH 2

2.1: chloroform; ethanol / 0.75 h / 60 - 63 °C

With ammonia; In ethanol; tert-butyl methyl ether; chloroform; water;

upstream raw materials:

(±)?3?(carbamoylmethyl)?5?methylhexanoic acid

1-phenylpropylamine

5-methyl-3-carboxymethylhexanoic acid

3-isobutylglutaric anhydride

Downstream raw materials:

(R,S)-3-iso-butyl-4-aminobutyric acid

(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid