181289-15-6Relevant articles and documents
Development of a new synthesis approach for S-pregabalin by optimizing the preparation stages
Mansoori, Arsalan,Zahednezhad, Fahimeh,Bavili Tabrizi, Ahad,Shahbazi Mojarrad, Javid
, p. 89 - 101 (2019/09/13)
In the present study, we aimed to optimize the synthesis stages of S-pregabalin ((S)-3-(aminomethyl)-5-methylhexanoic acid), a well-known anticonvulsant drug. We used appropriate solvents and compounds to reach a straightforward and applicable method. The advantages of this research were avoiding use of expensive and environment pollutant reagents and solvents, and also using a recoverable reagent. Discarding prevention of the intermediates and reagents besides attaining a higher yield of the obtained product were the additional achievements. All structures were characterized by FT-IR, 1H NMR, and the purity of S-pregabalin was evaluated using the HPLC assay.
Pregregregabalin intermediate mother liquor and method for recycling wastewater
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Paragraph 0032-0049, (2020/09/23)
The invention provides a preparation method for mechanically applying Pregabalin 3-isobutyl-glutarate monoamide intermediate mother liquid and waste water. The method comprises the following steps: (1) dropwise adding 3-isobutyl glutaric anhydride into stronger ammonia water with the mass fraction of 25-28%, and carrying out insulation reaction; (2) adding reclaimed waste water into the system, and then dropwise adding acid slowly into the system to adjust the pH value to be 2.0-3.0; (3) adding the mother liquid into the system, extracting with an organic solvent for layering, and then carrying out reduced pressure distillation on an organic layer; and (4) cooling to 5-15 DEG C within 2-3 hours, crystallizing, insulating for 1.5-2 hours, carrying out suction filtration, preserving suction filtration mother liquid, and baking filter cakes, thereby obtaining the target product 3-isobutyl-glutarate monoamide. The method provided by the invention has the advantages that the operation is simple, and the ammonolysis yield is effectively improved; before the ammonolysis mother liquid is mechanically applied, the yield is generally 70-85%; and after the ammonolysis mother liquid is mechanically applied, the yield can reach 99.0-102.0%, so that the productivity is effectively enlarged, and the cost of industrial production is lowered.
Method for synthesizing optically pure (R)-3-carbamoymethyl-5-methylhexanoic acid
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Paragraph 0019; 0021; 0026; 0028; 0033, (2019/09/14)
The invention relates to the technical field of fine chemical engineering production and in particular discloses a method for synthesizing optically pure (R)-3-carbamoymethyl-5-methylhexanoic acid. The method comprises the following steps: 1, synthesizing 2-cyano-5-methyl-2-ene ethyl hexanoate; 2, synthesizing 3-isobutyl-2-cyano-4-ethoxycarbonyl-ethyl glutarate; 3, synthesizing 3-isobutylglutaricanhydride; 4, synthesizing (+/-)-3-carbamoymethyl-5-methylhexanoic acid; and 5, synthesizing the (R)-3-carbamoymethyl-5-methylhexanoic acid. According to the method disclosed by the invention, the defects in the prior art are overcome, and the provided synthetic method is low in raw material cost, high in reaction speed, simple and feasible, is suitable for large-scale industrial production and has very high economic benefits.