2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester
• CAS No.: 187099-49-6
• Molecular Formula: C₁₆H₂₃NO₂Si
• Molecular Weight: 289.45
• Mol file: 187099-49-6.mol

Synonyms:2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester

Chemical Property of 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester

There total 8 articles about 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl 2-iodophenylcarbamate (161117-84-6) + trimethylsilylacetylene (1066-54-2) → 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester (187099-49-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 0.25h; Ambient temperature;

DOI:10.3987/com-96-7636

Reference yield: 67.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-[(trimethylsilyl)ethynyl]aniline (103529-16-4) → 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester (187099-49-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 50.0%

2-bromo-N-(tert-butoxycarbonyl)aniline (78839-75-5) + trimethylsilylacetylene (1066-54-2) → 2-((trimethylsilyl)ethynyl)phenylaminocarboxylic acid tert-butyl ester (187099-49-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 100 ℃; for 13h;

DOI:10.3987/com-96-7636

upstream raw materials:

2-bromo-N-(tert-butoxycarbonyl)aniline

trimethylsilylacetylene

tert-butyl 2-iodophenylcarbamate

di-tert-butyl dicarbonate

Downstream raw materials:

[2-(3-Methyl-but-2-enyl)-6-trimethylsilanylethynyl-phenyl]-carbamic acid tert-butyl ester

(2-Benzoyl-6-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester

indole

(2-Bromo-6-trimethylsilanylethynyl-phenyl)-carbamic acid tert-butyl ester