(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Base Information

Chemical Name:(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS No.:1575607-48-5
Molecular Formula:C₁₇H₁₈BrF₂N₇O
Molecular Weight:454.277
Hs Code.:

Synonyms:(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Chemical Property of (2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Technology Process of (2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

There total 6 articles about (2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.8%

: 1575612-75-7
3-bromo-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 1575607-48-5
(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: With lithium perchlorate; In acetonitrile; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jm4016284

Reference yield:

: 13105-78-7
N-benzyl-N-(2-hydroxyethyl)prop-2-yn-1-amine

: 1575607-48-5
(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; pyridine / dichloromethane / 2 h / 20 °C

1.2: 8 h / 80 °C

2.1: palladium(II) hydroxide; hydrogen / methanol / 50 °C

3.1: triethylamine / dichloromethane / 4 h / 20 °C

4.1: N-Bromosuccinimide / acetonitrile / 12 h / 60 °C

5.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C

6.1: lithium perchlorate / acetonitrile / 24 h / Inert atmosphere; Reflux

With pyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; hydrogen; lithium perchlorate; palladium(II) hydroxide; triethylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm4016284

Reference yield:

: 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine

: 1575607-48-5
(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 4 h / 20 °C

2: N-Bromosuccinimide / acetonitrile / 12 h / 60 °C

3: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C

4: lithium perchlorate / acetonitrile / 24 h / Inert atmosphere; Reflux

With hydrogenchloride; N-Bromosuccinimide; lithium perchlorate; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm4016284