(2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Base Information

Chemical Name:(2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS No.:1575607-67-8
Molecular Formula:C₂₁H₂₁F₂N₉O
Molecular Weight:453.454
Hs Code.:

Synonyms:(2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Chemical Property of (2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Technology Process of (2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

There total 7 articles about (2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 1575607-48-5
(2R, 3R)-3-(3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

: 321724-19-0
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

: 1575607-67-8
(2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 12h;
DOI:10.1021/jm4016284

Reference yield:

: 1575612-75-7
3-bromo-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine

: 1575607-67-8
(2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium perchlorate / acetonitrile / 24 h / Inert atmosphere; Reflux

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 12 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium perchlorate; caesium carbonate; In 1,4-dioxane; water; acetonitrile;
DOI:10.1021/jm4016284

Reference yield:

: 13105-78-7
N-benzyl-N-(2-hydroxyethyl)prop-2-yn-1-amine

: 1575607-67-8
(2R,3R)-3-(3-(pyrimidin-5-yl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride; pyridine / dichloromethane / 2 h / 20 °C

1.2: 8 h / 80 °C

2.1: palladium(II) hydroxide; hydrogen / methanol / 50 °C

3.1: triethylamine / dichloromethane / 4 h / 20 °C

4.1: N-Bromosuccinimide / acetonitrile / 12 h / 60 °C

5.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C

6.1: lithium perchlorate / acetonitrile / 24 h / Inert atmosphere; Reflux

7.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 12 h / 80 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; hydrogen; lithium perchlorate; palladium(II) hydroxide; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm4016284