(4R,2'R,3'S,4'S)-3-(5'-Benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-4-isopropyl-2-oxazolidinone

Base Information

Chemical Name:(4R,2'R,3'S,4'S)-3-(5'-Benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-4-isopropyl-2-oxazolidinone
CAS No.:97747-36-9
Molecular Formula:C₂₀H₂₉NO₅
Molecular Weight:363.454
Hs Code.:

Synonyms:(4R,2'R,3'S,4'S)-3-(5'-Benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-4-isopropyl-2-oxazolidinone

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Chemical Property of (4R,2'R,3'S,4'S)-3-(5'-Benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-4-isopropyl-2-oxazolidinone

Chemical Property:

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Technology Process of (4R,2'R,3'S,4'S)-3-(5'-Benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-4-isopropyl-2-oxazolidinone

There total 6 articles about (4R,2'R,3'S,4'S)-3-(5'-Benzyloxy-3'-hydroxy-2',4'-dimethylpentanoyl)-4-isopropyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5658-46-8
((2-methylallyloxy)methyl)benzene

: 87702-54-3,87758-65-4,97747-36-9
(S)-3-((2R,3S)-5-Benzyloxy-3-hydroxy-2,4-dimethyl-pentanoyl)-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BH₃*SMe₂ / 1.) THF, 2.) NaOH, H₂O₂

2: PCC / CH₂Cl₂

3: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C-0 deg C; 2.) -78 deg C - 20 deg C, 1.5 h, 3.) H₂O₂, MeOH, 0 deg C

With dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/S0040-4039(00)86280-2

Reference yield:

: 63930-46-1,63930-49-4,56850-59-0,64839-09-4
3-(benzyloxy)-2-methylpropan-1-ol

: 87702-54-3,87758-65-4,97747-36-9
(S)-3-((2R,3S)-5-Benzyloxy-3-hydroxy-2,4-dimethyl-pentanoyl)-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: PCC / CH₂Cl₂

2: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C-0 deg C; 2.) -78 deg C - 20 deg C, 1.5 h, 3.) H₂O₂, MeOH, 0 deg C

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/S0040-4039(00)86280-2

Reference yield:

: 100-39-0
benzyl bromide

: 87702-54-3,87758-65-4,97747-36-9
(S)-3-((2R,3S)-5-Benzyloxy-3-hydroxy-2,4-dimethyl-pentanoyl)-4-isopropyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: 1.) BH₃*SMe₂ / 1.) THF, 2.) NaOH, H₂O₂

3: PCC / CH₂Cl₂

4: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C-0 deg C; 2.) -78 deg C - 20 deg C, 1.5 h, 3.) H₂O₂, MeOH, 0 deg C

With dimethylsulfide borane complex; di-n-butylboryl trifluoromethanesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)86280-2