(R)-diethyl 2-phenylsuccinate

Base Information

Chemical Name:(R)-diethyl 2-phenylsuccinate
CAS No.:1354896-76-6
Molecular Formula:C₁₄H₁₈O₄
Molecular Weight:250.295
Hs Code.:

Synonyms:(R)-diethyl 2-phenylsuccinate

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Chemical Property of (R)-diethyl 2-phenylsuccinate

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Technology Process of (R)-diethyl 2-phenylsuccinate

There total 6 articles about (R)-diethyl 2-phenylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 64-17-5
ethanol

: ethyl (R)-4-oxo-3-phenyl-4-(1-(o-tolyl)-1H-imidazol-2-yl)butanoate

: 1354896-76-6
(R)-diethyl 2-phenylsuccinate

Guidance literature:: ethyl (R)-4-oxo-3-phenyl-4-(1-(o-tolyl)-1H-imidazol-2-yl)butanoate; With methyl trifluoromethanesulfonate; In acetonitrile; at 0 ℃; for 6h; Molecular sieve; Inert atmosphere;

ethanol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 ℃; for 1h; Molecular sieve; Inert atmosphere;
DOI:10.1021/jacs.6b07692

Reference yield:

: 623-91-6
diethyl Fumarate

: 98-80-6
phenylboronic acid

: 1354896-76-6
(R)-diethyl 2-phenylsuccinate

: 34861-81-9
(S)-diethyl 2-phenylsuccinate

Guidance literature:: phenylboronic acid; With chlorobis(ethylene)rhodium(I) dimer; (S,S)-1,7,7-trimethyl-2,5-diphenylbicyclo[2.2.1]hepta-2,5-diene; potassium hydroxide; In methanol; dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

diethyl Fumarate; In methanol; dichloromethane; isopropyl alcohol; at 60 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol300980k

Reference yield:

: 64-17-5
ethanol

: ethyl (E)-4-oxo-2-phenylbut-2-enoate

: 1354896-76-6
(R)-diethyl 2-phenylsuccinate

: 34861-81-9
(S)-diethyl 2-phenylsuccinate

Guidance literature:: With (S)-5-benzyl-2-mesityl-6,6-dimethyl-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate; 3,4-bis((3,5-bis(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine; In water; 1,2-dichloro-ethane; at 0 ℃; for 48h; Reagent/catalyst; Temperature; Overall yield = 85 %; Overall yield = 41 mg; Optical yield = 88 %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jacs.5b02887