ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate

Base Information

• Chemical Name: ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate
• CAS No.: 1444311-28-7
• Molecular Formula: C₁₉H₂₄N₂O₄
• Molecular Weight: 344.411
• Mol file: 1444311-28-7.mol

Synonyms:ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate

Chemical Property of ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate

There total 3 articles about ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-isopropyl-4-(3-methoxybenzyl)pyridazin-3(2H)-one (1444311-17-4) + ethyl bromoacetate (105-36-2) → ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate (1444311-28-7)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.ejmech.2013.03.066

Reference yield:

5-Methyl-4-oxohexanoic acid (41654-04-0) → ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate (1444311-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 60 °C

2: potassium hydroxide / ethanol / Reflux

3: potassium carbonate / acetonitrile / Reflux

With hydrazine hydrate; potassium carbonate; potassium hydroxide; In ethanol; acetonitrile; 2: |Knoevenagel Condensation;

DOI:10.1016/j.ejmech.2013.03.066

Reference yield:

6-isopropyl-4,5-dihydro-3(2H) pyridazinone (210230-80-1) → ethyl 2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate (1444311-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / Reflux

2: potassium carbonate / acetonitrile / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetonitrile; 1: |Knoevenagel Condensation;

DOI:10.1016/j.ejmech.2013.03.066

upstream raw materials:

5-Methyl-4-oxohexanoic acid

6-isopropyl-4,5-dihydro-3(2H) pyridazinone

6-isopropyl-4-(3-methoxybenzyl)pyridazin-3(2H)-one

ethyl bromoacetate

Downstream raw materials:

2-[3-isopropyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetic acid