[4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid

Base Information

Chemical Name:[4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid
CAS No.:867359-86-2
Molecular Formula:C₁₇H₂₂ClFN₂O₄
Molecular Weight:372.824
Hs Code.:

Synonyms:[4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid

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Technology Process of [4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid

There total 1 articles about [4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 144432-85-9
3-chloro-4-fluorophenylboronic acid

: 298-12-4
Glyoxilic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 867359-86-2
[4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid

Guidance literature:: In dichloromethane; Heating / reflux;

Reference yield: 83.0%

: 867359-86-2
[4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid

: 867359-85-1
tert-butyl 4-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate

Guidance literature:: [4-(tert-butoxycarbonyl)piperazin-1-yl](3-chloro-4-fluorophenyl)acetic acid; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 4.5h; Heating / reflux;

With methanol; In tetrahydrofuran;