144432-85-9

Basic information

• Product Name: 3-Chloro-4-fluorophenylboronic acid
• Synonyms: Boronic acid, B-(3-chloro-4-fluorophenyl)-;3-Chloro-4-fluorobenzeneboronic acid (contains varying aMounts of anhydride);B-(3-chloro-4-fluorophenyl)-Boronic acid;Boronic acid,(3-chloro-4-fluorophenyl)-;(3-Chloro-4-fluorophenyl-1-yl)boronic acid;3-CHLORO-4-FLUOROPHENYLBORONIC ACID;3-CHLORO-4-FLUOROBENZENEBORONIC ACID;4-FLUORO-3-CHLOROPHENYLBORONIC ACID
• CAS NO: 144432-85-9
• Molecular Formula: C₆H₅BClFO₂
• Molecular Weight: 174.37
• EINECS: -0
• Product Categories: Fluorin-contained phenyl boronic acid series;blocks;BoronicAcids;FluoroCompounds;Boric Acid;Boronic Acid series;Substituted Boronic Acids;Benzene series;Fluorobenzene;Boronic Acid;Aryl;Organoborons;B (Classes of Boron Compounds);Boronic Acids
• Mol File: 144432-85-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 242-247 °C(lit.)
• Boiling Point: 306 °C at 760 mmHg
• Flash Point: 138.8 °C
• Appearance: Off-white to faintly orange/Powder
• Density: 1.41 g/cm³
• Storage Temp.: Refrigerator (+4°C)
• Solubility: soluble in Methanol
• PKA: 7?+-.0.10(Predicted)
• BRN: 7369789
• CAS DataBase Reference: 3-Chloro-4-fluorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-fluorophenylboronic acid(144432-85-9)
• EPA Substance Registry System: 3-Chloro-4-fluorophenylboronic acid(144432-85-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 144432-85-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to faintly orange powder

Uses

Different sources of media describe the Uses of 144432-85-9 differently. You can refer to the following data:
1. suzuki reaction
2. 3-Chloro-4-fluorophenylboronic Acid is a reactant that has been used in the synthesis of 2-bromo-3-hexyl-5-(4-iodophenyl)thiophene, which has shown high anti-thrombolytic activity.
3. Reactant for:Rh-catalyzed asymmetric addition reactionsPalladium-catalyzed oxidative cross-coupling reactionSuzuki-Miyaura coupling

Upstream product

• 60811-21-4 1-bromo-3-chloro-4-fluorobenzene 

Downstream Products

• 57455-06-8 3-iodobenzylalcohol 
• 861218-28-2 4-(3-chloro-4-fluoro-phenyl)-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 860617-54-5 6-(3-chloro-4-fluorophenyl)-1-(1-ethylpropyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 871817-19-5 2-(3-chloro-4-fluoro-phenyl)-[1,3,2]dioxaborolane 
• 799293-86-0 4-amino-3-(3-chloro-4-fluoro-phenyl)-thieno[3,2-c]pyridine 
• 335063-18-8 5-(3-chloro-4-fluoro-phenyl)-4-[4-(5-methyl-1H-imidazol-4-yl)-piperidin-1-yl]-pyrimidine 

Relevant articles and documents

An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids

3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench". This technique was further studied and evaluated on other aryl halides in the preparation of arylboronic acids.