trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

Base Information

Chemical Name:trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid
CAS No.:307989-26-0
Molecular Formula:C₂₃H₃₅NO₄
Molecular Weight:389.535
Hs Code.:

Synonyms:trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

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Chemical Property of trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

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Technology Process of trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

There total 7 articles about trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5400-88-4
4-tert-butylcyclohexylamine

: 307989-26-0
trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 23 h / 20 - 100 °C

2: DIPEA / tetrahydrofuran / 20 °C

3: 24.3 g / aq. NaOH; ethanol / 4 h / 70 °C

With sodium hydroxide; ethanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm058026u

Reference yield:

: 307990-36-9
4-{[tert-butoxycarbonyl-(4-tert-butyl-cyclohexyl)-amino]-methyl}-benzoic acid methyl ester

: 307989-26-0
trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

Guidance literature:: With sodium hydroxide; ethanol; at 70 ℃; for 4h;
DOI:10.1021/jm058026u

Reference yield:

: 307989-24-8
trans-4-[(4-tert-butylcyclohexylimino)methyl]benzoic acid methyl ester

: 307989-26-0
trans-4-{[N-(tert-butoxycarbonyl)-N-(4-tert-butylcyclohexyl)amino]methyl}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / acetic acid; NaCNBH₃ / methanol / 0.5 h / 20 °C

2: DIPEA / tetrahydrofuran / 20 °C

3: 24.3 g / aq. NaOH; ethanol / 4 h / 70 °C

With sodium hydroxide; ethanol; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm058026u