(4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

Base Information

Chemical Name:(4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine
CAS No.:629648-06-2
Molecular Formula:C₂₃H₃₂N₂O₆
Molecular Weight:432.517
Hs Code.:

Synonyms:(4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

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Chemical Property of (4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

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Technology Process of (4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

There total 2 articles about (4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 100-46-9
benzylamine

: 629648-03-9
(4S)-4-[3-oxo-5-(4'-methylphenylsulfonyl)-1-pentenyl]-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

: 629648-11-9
(4S,2'S)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

: 629648-06-2
(4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

Guidance literature:: benzylamine; (4S)-4-[3-oxo-5-(4'-methylphenylsulfonyl)-1-pentenyl]-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine; In tetrahydrofuran; at 0 ℃; for 144h;

With palladium dihydroxide; hydrogen; In methanol; at 25 ℃; for 20h; under 2585.74 Torr;

benzyl chloroformate; With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2003.08.060

Reference yield:

: 95715-87-0
(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

: 629648-06-2
(4S,2'R)-4-(1'-benzyloxycarbonyl-4'-oxopiperidin-2'-yl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / CHCl₃ / 20 h / Heating

2.1: tetrahydrofuran / 144 h / 0 °C

2.2: H₂; Pd(OH)2 / methanol / 20 h / 25 °C / 2585.74 Torr

2.3: 1.07 g / Na₂CO₃*10H₂O / tetrahydrofuran; H₂O / 16 h / 20 °C

In tetrahydrofuran; chloroform; 2.1: Michael reaction;
DOI:10.1016/j.tet.2003.08.060