cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

Base Information

Chemical Name:cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate
CAS No.:205694-32-2
Molecular Formula:C₃₀H₃₉N₃O₇
Molecular Weight:553.656
Hs Code.:

Synonyms:cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

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Chemical Property of cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

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Technology Process of cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

There total 5 articles about cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1878-88-2
2-(3-nitrophenoxy)acetic acid

: 205694-32-2
cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: DMF, SOCl₂ / 0.5 h / Heating

2: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: H₂ / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr

4: EDC*HCl, DMAP / CH₂Cl₂ / Ambient temperature

5: 1.) NaH / 1.) THF, 60 deg C, 15 min, 2.) THF, RT, 1.5 h

With pyridine; dmap; thionyl chloride; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434

Reference yield:

: 40257-02-1
3-nitrophenoxyacetyl chloride

: 205694-32-2
cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr

3: EDC*HCl, DMAP / CH₂Cl₂ / Ambient temperature

4: 1.) NaH / 1.) THF, 60 deg C, 15 min, 2.) THF, RT, 1.5 h

With pyridine; dmap; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434

Reference yield:

: 205694-09-3
cyclohexyl 2-(3-nitrophenoxy)acetate

: 205694-32-2
cyclohexyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr

2: EDC*HCl, DMAP / CH₂Cl₂ / Ambient temperature

3: 1.) NaH / 1.) THF, 60 deg C, 15 min, 2.) THF, RT, 1.5 h

With dmap; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434