1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

Base Information

Chemical Name:1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate
CAS No.:1032823-37-2
Molecular Formula:C₂₂H₂₈N₂O₅S
Molecular Weight:432.541
Hs Code.:

Synonyms:1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

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Chemical Property of 1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

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Technology Process of 1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

There total 2 articles about 1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1010113-01-5
tert-butyl 4-((6-(4-(methylsulfonyl)phenyl)pyridine-3-yloxy)methyl)piperidin-1-carboxylate

: 108-23-6
isopropyl chloroformate

: 1032823-37-2
1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

Guidance literature:: tert-butyl 4-((6-(4-(methylsulfonyl)phenyl)pyridine-3-yloxy)methyl)piperidin-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

isopropyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield: 81.0%

: 1032825-08-3
4-(6-bromopyridin-3-yloxymethyl)piperidine-1-carboxylic acid isopropyl ester

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1032823-37-2
1-Methylethyl 4-[({6-[4-(methylsulfonyl)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 6h; Product distribution / selectivity;