N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1236405-08-5
Molecular Formula:C₂₃H₂₂N₂O₄
Molecular Weight:390.439
Hs Code.:

Synonyms:N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 7 articles about N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₀N₂O₅

: 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate

: 1236405-08-5
N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: C₁₉H₂₀N₂O₅; 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bistetrafluoroborate; With morpholine; In butan-1-ol; at 80 ℃; for 14h;

With water; acetic acid; In water; at 20 ℃; for 4h;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1236405-08-5
N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene; hexane; methanol / 0.5 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

4.2: 0 °C

5.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

6.1: morpholine / butan-1-ol / 14 h / 80 °C

6.2: 4 h / 20 °C

With morpholine; lithium aluminium tetrahydride; water; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; ISOPROPYLAMIDE; toluene; butan-1-ol;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1236405-08-5
N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

2.2: 0 °C

3.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

4.1: morpholine / butan-1-ol / 14 h / 80 °C

4.2: 4 h / 20 °C

With morpholine; water; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; toluene; butan-1-ol;