N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1236404-70-8
Molecular Formula:C₂₇H₃₁N₃O₃
Molecular Weight:445.561
Hs Code.:

Synonyms:N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 8 articles about N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 2516-34-9
cyclobutylamine

: 1236405-08-5
N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

: 1236404-70-8
N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: cyclobutylamine; N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide; With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1236404-70-8
N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene; hexane; methanol / 0.5 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

4.2: 0 °C

5.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

6.1: morpholine / butan-1-ol / 14 h / 80 °C

6.2: 4 h / 20 °C

7.1: acetic acid / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

7.2: 3 h / 20 °C

With morpholine; lithium aluminium tetrahydride; water; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; hexane; ISOPROPYLAMIDE; toluene; butan-1-ol;

Reference yield:

: 97-99-4,22415-59-4,57203-01-7,72074-94-3
(S)-(tetrahydrofuran-2-yl)methanol

: 1236404-70-8
N-{3-[(cyclobutylamino)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 80 °C

2.2: 0 °C

3.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

4.1: morpholine / butan-1-ol / 14 h / 80 °C

4.2: 4 h / 20 °C

5.1: acetic acid / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

5.2: 3 h / 20 °C

With morpholine; water; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ISOPROPYLAMIDE; toluene; butan-1-ol;