[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

Base Information

Chemical Name:[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone
CAS No.:886854-84-8
Molecular Formula:C₁₇H₁₆BrN₅O₂
Molecular Weight:402.25
Hs Code.:

Synonyms:[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

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Chemical Property of [4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

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Technology Process of [4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

There total 4 articles about [4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 51207-86-4
(4-amino-phenyl)-morpholin-4-yl-methanone

: 886854-84-8
[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 90 ℃;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 886854-83-7
4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid

: 886854-84-8
[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

Guidance literature:: 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 0.333333h;

morpholine; at 20 ℃; for 16h;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 886854-84-8
[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;