N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide

Base Information

Chemical Name:N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide
CAS No.:19462-25-0
Molecular Formula:C₁₉H₂₀N₂O
Molecular Weight:292.381
Hs Code.:
DSSTox Substance ID:DTXSID001222491

Synonyms:N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide;DTXSID001222491;19462-25-0

Suppliers and Price of N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:292.157563266
Heavy Atom Count:22
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(CCC1=CNC2=CC=CC=C21)C(=O)CC3=CC=CC=C3

Technology Process of N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide

There total 3 articles about N-[2-(1H-Indol-3-yl)ethyl]-N-methylbenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 61-49-4
[2-(1H-indol-3-yl)-ethyl]-methylamine

: 103-80-0
phenylacetyl chloride

: 19462-25-0
N-(2-indol-3-yl-ethyl)-N-methyl-2-phenyl-acetamide

Guidance literature:: [2-(1H-indol-3-yl)-ethyl]-methylamine; With sodium hydroxide; In dichloromethane; at 0 ℃; for 0.0833333h;

phenylacetyl chloride; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/b518019h

Reference yield:

: 61-54-1
tryptamine

: 19462-25-0
N-(2-indol-3-yl-ethyl)-N-methyl-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / aq. NaOH / CHCl₃ / 3 h / 20 °C

2.1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

3.1: aq. NaOH / CH₂Cl₂ / 0.08 h / 0 °C

3.2: 55 percent / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1039/b518019h

Reference yield:

: 67909-99-3
ethyl 2-(1H-indole-3-yl)ethylcarbamate

: 19462-25-0
N-(2-indol-3-yl-ethyl)-N-methyl-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2.1: aq. NaOH / CH₂Cl₂ / 0.08 h / 0 °C

2.2: 55 percent / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b518019h