tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate
CAS No.:1433992-82-5
Molecular Formula:C₂₀H₂₃N₃O₃
Molecular Weight:353.421
Hs Code.:

Synonyms:tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

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Chemical Property of tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

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Technology Process of tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

There total 5 articles about tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1433992-81-4
3-benzyl-4,5-dihydro-1H-pyrido[2,3-e][1,4]diazepin-2(3H)-one

: 1433992-82-5
tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: In dichloromethane; acetonitrile; Reflux;

Reference yield:

: 38427-94-0
N-(tert-butoxycarbonyl)-2-aminopyridine

: 1433992-82-5
tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / diethyl ether / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 0.17 h / 0 °C

2.1: acetic acid / dichloromethane / 1 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / methanol / 2 h / 20 °C

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

5.1: dichloromethane; acetonitrile / Reflux

With hydrogenchloride; tert.-butyl lithium; sodium hydride; acetic acid; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 116026-94-9
2--3-pyridinecarboxaldehyde

: 1433992-82-5
tert-butyl 3-benzyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 1 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / methanol / 2 h / 20 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane; acetonitrile / Reflux

With hydrogenchloride; sodium hydride; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;