(Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Base Information

Chemical Name:(Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate
CAS No.:1433997-71-7
Molecular Formula:C₂₄H₃₂N₄O₄
Molecular Weight:440.542
Hs Code.:

Synonyms:(Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

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Chemical Property of (Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

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Technology Process of (Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

There total 8 articles about (Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1433992-84-7
tert-butyl 3-benzyl-2-(methylthio)-3H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

: 22483-09-6
2,2-dimethoxyethylamine

: 1433997-71-7
(Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: at 90 ℃; for 1h; Sealed tube; Microwave irradiation;

Reference yield:

: methyl 2-((2-(tert-butoxycarbonylamino)pyridin-3-yl)methylamino)-3-phenylpropanoate

: 1433997-71-7
(Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / methanol / 2 h / 20 °C

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

3: dichloromethane; acetonitrile / Reflux

4: Lawessons reagent / toluene / 3 h / 90 °C

5: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

6: 1 h / 90 °C / Sealed tube; Microwave irradiation

With Lawessons reagent; hydrogenchloride; sodium hydride; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 116026-94-9
2--3-pyridinecarboxaldehyde

: 1433997-71-7
(Z)-tert-butyl 3-benzyl-2-(2,2-dimethoxyethylimino)-2,3-dihydro-1H-pyrido[2,3-e][1,4]diazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / dichloromethane / 1 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / methanol / 2 h / 20 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane; acetonitrile / Reflux

5.1: Lawessons reagent / toluene / 3 h / 90 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: 1 h / 90 °C / Sealed tube; Microwave irradiation

With Lawessons reagent; hydrogenchloride; sodium hydride; potassium carbonate; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;